beta 2 Adrenergic Receptor (BAR2) Antibody (N-term) Blocking peptide

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.

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Synthetic peptide

The synthetic peptide sequence used to generate the antibody AP7263a was selected from the N-term region of human BAR2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.