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TDG Antibody (N-term) Blocking Peptide

TDG Antibody (N-term) Blocking Peptide

Item no.	ABC-BP6624a
Manufacturer	Abcepta
Amount	500 ug
Category	Peptides & Proteins Peptides
Type	Peptides
Format	Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Similar products	TDG, G/T mismatch-specific thymine DNA glycosylase, Thymine-DNA glycosylase, hTDG
Available
Primary Accession	Q13569
Bio Background	The protein TDG belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine.
Bio References	Kim, E.J., Biochem. Biophys. Res. Commun. 377 (3), 838-842 (2008)Neddermann, P., J. Biol. Chem. 271 (22), 12767-12774 (1996)
Gene ID	6996
Gene Name	TDG
Subtitle	Synthetic peptide
Target/Specificity	The synthetic peptide sequence used to generate the antibody AP6624a was selected from the N-term region of human TDG. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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ABC-BP6624a-datasheet.pdf

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Amount: 500 ug

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Delivery expected until 10/4/2024

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