Item no. |
ABC-BP3782a |
Manufacturer |
Abcepta
|
Amount |
500 ug |
Category |
|
Type |
Peptides |
Format |
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Similar products |
IKBKB, IKKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta, IKK-beta, IKK2, NFKBIKB, IkBKB, I-kappa-B-kinase beta, IKK-B |
Available |
|
Primary Accession |
O14920 |
Bio Background |
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL(MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form theNFKB complex. The NFKB complex is inhibited by I-kappa-B proteins(NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivateNF-kappa-B by trapping it in the cytoplasm. Phosphorylation ofserine residues on the I-kappa-B proteins by kinases (IKBKA, MIM600664, or IKBKB) marks them for destruction via the ubiquitinationpathway, thereby allowing activation of the NF-kappa-B complex.Activated NFKB complex translocates into the nucleus and binds DNAat kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or Gpurine; and Y is a C or T pyrimidine). |
Bio References |
Yatherajam, G., et al. J. Immunol. 185(5):2665-2669(2010)Kenneth, N.S., et al. EMBO J. 29(17):2966-2978(2010)Zhao, M., et al. J. Biol. Chem. 285(32):24372-24380(2010)Niida, M., et al. Mol. Immunol. 47(14):2378-2387(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010) |
Gene ID |
3551 |
Gene Name |
IKBKB |
Subtitle |
Synthetic peptide |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.