Item no. |
ABC-BP3559a |
Manufacturer |
Abcepta
|
Amount |
500 ug |
Category |
|
Type |
Peptides |
Format |
Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Similar products |
RUNX2, CBFA1, OSF2, AML3, PEBP2A, Runt-related transcription factor 2, Acute myeloid leukemia 3 protein, Core-binding factor subunit alpha-1, Oncogene AML-3, Osteoblast-specific transcription factor 2, CBF-alpha-1, Polyomavirus enhancer-binding protein 2 alpha A subunit, PEBP2-alpha A, PEA2-alpha A, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit, OSF-2 |
Available |
|
Primary Accession |
Q13950 |
Bio Background |
Runx2 is a member of the RUNX family of transcription factors. It is a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in the Runx2 gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). |
Bio References |
Rich, J.T., Biochem. Biophys. Res. Commun. 372 (1), 230-235 (2008)Ermakov, S., Ann. Hum. Genet. 72 (PT 4), 510-518 (2008)Endo, T., J. Clin. Endocrinol. Metab. 93 (6), 2409-2412 (2008) |
Gene ID |
860 |
Gene Name |
RUNX2 |
Subtitle |
Synthetic peptide |
Target/Specificity |
The synthetic peptide sequence used to generate the antibody AP3559a was selected from the region of human Phospho-RUNX2-pS465. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.