Bio Background |
USP21 is a ubiquitin-specific protease, an enzyme that removes ubiquitin from ubiquitinated proteins. The encoded protein belongs to the C19 peptidase family, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. This protein has been reported to be capable of removing NEDD8 from NEDD8 conjugates. |
Bio References |
Puente, X.S., et al., Nat. Rev. Genet. 4(7):544-558 (2003). Gong, L., et al., J. Biol. Chem. 275(19):14212-14216 (2000). Hillier, L.D., et al., Genome Res. 6(9):807-828 (1996). Smith, T.S., et al., Biochim. Biophys. Acta 1490 (1-2), 184-188 (2000). |