KRT86 Blocking Peptide (Center)

The protein encoded by this gene is a member of the
keratin gene family. As a type II hair keratin, it is a basic
protein which heterodimerizes with type I keratins to form hair and
nails. The type II hair keratins are clustered in a region of
chromosome 12q13 and are grouped into two distinct subfamilies
based on structure similarity. One subfamily, consisting of KRTHB1,
KRTHB3, and KRTHB6, is highly related. The other less-related
subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins
are expressed in the hair follicle; this hair keratin, as well as
KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations
in this gene and KRTHB1 have been observed in patients with a rare
dominant hair disease, monilethrix.

3892

Synthetic peptide

The synthetic peptide sequence is selected from aa 315-327 of HUMAN KRT86