Similar products |
NIP1, NCBP2, CBP20, Nuclear cap-binding protein subunit 2, 20 kDa nuclear cap-binding protein, Cell proliferation-inducing gene 55 protein, NCBP 20 kDa subunit, NCBP-interacting protein 1 |
Bio Background |
NCBP2 is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. NCBP2 has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. |
Bio References |
Calero, G., et al., Nat. Struct. Biol. 9(12):912-917 (2002).Mazza, C., et al., EMBO J. 21(20):5548-5557 (2002).Kataoka, N., et al., Nucleic Acids Res. 23(18):3638-3641 (1995).Izaurralde, E., et al., Nature 376(6542):709-712 (1995). |