Bio Background |
The protein encoded by this gene is a caspase-3 substratethat plays a role in regulating microfilament and cell shapechanges during apoptosis. It can also modulate cell susceptibilityto p53-dependent apoptosis by inhibiting calpain activity. Multiplealternatively spliced variants, encoding the same protein, havebeen identified. |
Bio References |
Huang, W., et al. Mol. Cell. Biol. 30(19):4575-4594(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Benetti, R., et al. J. Biol. Chem. 280(23):22070-22080(2005)Tsutsumi, S., et al. Am. J. Hum. Genet. 74(6):1255-1261(2004)Benetti, R., et al. EMBO J. 20(11):2702-2714(2001) |