Bio Background |
The protein encoded by this gene belongs to the integrinalpha chain family. Integrins are heterodimeric integral membraneproteins composed of an alpha chain and a beta chain. They mediatea wide spectrum of cell-cell and cell-matrix interactions, and thusplay a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as areceptor for the basement membrane protein laminin-1. It is mainlyexpressed in skeletal and cardiac muscles and may be involved indifferentiation and migration processes during myogenesis. Defectsin this gene are associated with congenital myopathy. Alternativelyspliced transcript variants encoding different isoforms have beennoted for this gene. |
Bio References |
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Han, Y.C., et al. Cancer Res. 70(11):4375-4384(2010)Rooney, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(19):7991-7996(2009)Liu, J., et al. J. Biol. Chem. 283(51):35668-35678(2008)Tran, T., et al. Am. J. Respir. Cell Mol. Biol. 37(6):668-680(2007) |