FBXO8 Antibody (Center) Blocking Peptide

This gene encodes a member of the F-box protein familywhich is characterized by an approximately 40 amino acid motif, theF-box. The F-box proteins constitute one of the four subunits ofthe ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependentubiquitination. The F-box proteins are divided into 3 classes: Fbwscontaining WD-40 domains, Fbls containing leucine-rich repeats, andFbxs containing either different protein-protein interactionmodules or no recognizable motifs. The protein encoded by this genebelongs to the Fbxs class. It contains a C-terminal amino acidsequence that bears a significant similarity with a portion ofyeast Sec7p, a critical regulator of vesicular protein transport.This human protein may interact with ADP-ribosylationfactor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchangefactor) activity.

Synthetic peptide