LEPR Antibody (C-term) Blocking Peptide

The protein encoded by this gene belongs to the gp130family of cytokine receptors that are known to stimulate genetranscription via activation of cytosolic STAT proteins. Thisprotein is a receptor for leptin (an adipocyte-specific hormonethat regulates body weight), and is involved in the regulation offat metabolism, as well as in a novel hematopoietic pathway that isrequired for normal lymphopoiesis. Mutations in this gene have beenassociated with obesity and pituitary dysfunction. Alternativelyspliced transcript variants encoding different isoforms have beendescribed for this gene. It is noteworthy that this gene and LEPROTgene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).

3953

Synthetic peptide