KCNA1 Antibody (Center) Blocking Peptide

This gene encodes a voltage-gated delayed potassiumchannel that is phylogenetically related to the Drosophila Shakerchannel. The encoded protein has six putative transmembranesegments (S1-S6), and the loop between S5 and S6 forms the pore andcontains the conserved selectivity filter motif (GYGD). Thefunctional channel is a homotetramer. The N-terminus of the channelis associated with beta subunits that can modify the inactivationproperties of the channel as well as affect expression levels. TheC-terminus of the channel is complexed to a PDZ domain protein thatis responsible for channel targeting. Mutations in this gene havebeen associated with myokymia with periodic ataxia (AEMK).

3736

Synthetic peptide