Bio Background |
Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatinstructures. This gene encodes a member of the histone H1 family. |
Bio References |
Warneboldt, J., et al. BMC Cancer 8, 388 (2008) :Stoldt, S., et al. Biol. Cell 99(10):541-552(2007)Takata, H., et al. FEBS Lett. 581(20):3783-3788(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006) |