Bio Background |
Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. This structure consists of approximately 146 bp of DNAwrapped around a nucleosome, an octamer composed of pairs of eachof the four core histones (H2A, H2B, H3, and H4). The chromatinfiber is further compacted through the interaction of a linkerhistone, H1, with the DNA between the nucleosomes to form higherorder chromatin structures. This gene is intronless and encodes amember of the histone H2A family. Transcripts from this gene lackpolyA tails; instead, they contain a palindromic terminationelement. This gene is found in the large histone gene cluster onchromosome 6p22-p21.3. |
Bio References |
Rose, J. Phd, et al. Mol. Med. (2010) In press :Bergink, S., et al. Genes Dev. 20(10):1343-1352(2006)Cao, R., et al. Mol. Cell 20(6):845-854(2005)Hagiwara, T., et al. Biochemistry 44(15):5827-5834(2005)Andersen, J.S., et al. Nature 433(7021):77-83(2005) |