InvivoChem Cat #:V9837CAS #:111974-69-7Purity >=98%Description: QuetiapineFumarate (also known as ICI 204636; marketed as Seroquel) is an atypical antipsychotic agentacting as a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1Areceptor, used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression. The antipsychotic effect ofquetiapine might be mediated through antagonist activity at dopamineand serotonin receptors. Quetiapine specifically antagonized the D1 andD2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adreno-receptor, and5-HT1A and 5-HT2 serotonin receptor subtypes.
References: J Clin Psychiatry. 2002; 63 Suppl 13:5-11; Hippocampus. 2006; 16(6):551-9.
Related CAS #: 111974-72-2 (hemifumarate); 111974-69-7 (free base)
Description: QuetiapineFumarate (also known as ICI 204636; marketed as Seroquel) is an atypical antipsychotic agentacting as a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1Areceptor, used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression. The antipsychotic effect ofquetiapine might be mediated through antagonist activity at dopamineand serotonin receptors. Quetiapine specifically antagonized the D1 andD2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adreno-receptor, and5-HT1A and 5-HT2 serotonin receptor subtypes.
References: J Clin Psychiatry. 2002; 63 Suppl 13:5-11; Hippocampus. 2006; 16(6):551-9.
Related CAS #: 111974-72-2 (hemifumarate); 111974-69-7 (free base)