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Description: BDP9066 is a novel, potent and selective MRCK (myotonic dystrophy-related Cdc42-binding kinase) inhibitor (IC50 of 64 nM for MRCKbeta in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKalpha/beta in house determinations, respectively.), reducing substrate phosphorylation. BDP9066 leads to morphological changes in cancer cells along with inhibition of their motility and invasive character. It has therapeutic effect on skin cancer by reducing substrate phosphorylation.
References: Discoveryof Potent and Selective MRCK Inhibitors with Therapeutic Effect on SkinCancer. Cancer Res. 2018 Apr 15; 78(8):2096-2114.
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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