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Description: AZ1 is a novel and potent dual inhibitor of the USP25/28 deubiquitinating enzyme subfamily with potential anticancer activity. It has been reported that Ubiquitin specific proteases (USPs) are linked to critical axes for therapeutic intervention and USP28 is required for c-Myc stability, suggesting thatUSP28 inhibition may represent a novel approach to targeting this so farundruggable oncogene.
Reference: ACS Chem Biol. 2017 Dec 15; 12(12):3113-3125. doi: 10.1021/acschembio.7b00334.
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