InvivoChem Cat #:V7475CAS #:393121-74-9Purity >=98%Description: AA147 is an ATF6 simulator. It acts as a prodrug that preferentially triggers ATF6 signaling through a mechanism involving localized metabolic activation and selective covalent modification of ER resident proteins regulate ATF6 activity.
References: Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL, Glembotski CC. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nat Commun. 2019 Jan 14; 10(1):187. doi: 10.1038/s41467-018-08129-2.