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Description: Quinine is a naturally occuring anti-malaria agent which acts as a potassium channel inhibitor with an IC50 of 169 uM, also has antipyretic (fever-reducing), analgesic (painkilling), anti-inflammatory properties and a bitter taste. It is a stereoisomer of of quinidine which contains an aromatic quinoline and a bicyclic quinuclidine. Quinine prevents formation of tumor necrosis factor (TNF) as well as the subsequent hepatic DNA fragmentation and liver enzyme leakage. Quinine elicits Fos-like immunoreactivity (FLI) concentrated in the medial third of the nucleus.
References: Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10942-7; Eur J Pharmacol. 1995 Dec 27; 294(1):353-5.
Related CAS #: 130-95-0 (Quinine free base); 6119-47-7 (Quinine HCl dihydrate)
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