« Back
Home /
isavuconazole

isavuconazole

Item no.	V5312-500mg
Manufacturer	InvivoChem LLC
CASRN	241479-67-4
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V5312CAS #:241479-67-4Purity >=98% Description: Isavuconazole (also knownc as BAL-4815 and RO-0094815), a water-soluble triazole, is a novel and potent inhibitor of CYP3A4 with broad-spectrum antifungal activity. Its prodrug, isavuconazonium sulfate (known also as BAL-8557), was approved by the U.S. Food and Drug Administration (FDA) on March 6, 2015 for the treatment of invasive candidiasis. Isavuconazole works by inhibiting lanosterol 14 alpha-demethylase, the enzyme responsible for converting lanosterol to ergosterol by demethylation. The resulting depletion of ergosterol and build up of lanosterol compromise the structure of the fungal cell membrane. Mammalian cells are resistant to demethylation inhibition by azoles, making the drug effects specific to fungi. References: Antimicrob Agents Chemother. 2007 May; 51(5):1818-21.; Antimicrob Agents Chemother. 2016 Oct 21; 60(11):6890-6891. Related CAS: 338990-84-4 (BAL8557 chloride); 497235-79-7 (BAL8557 chloride HCl); 742049-41-8 (BAL8557 cation); 946075-13-4 (BAL8557 sulfate)
	Name: Isavuconazole CAS#: 241479-67-4 Chemical Formula: C22H17F2N5OS Exact Mass: 437.1122 Molecular Weight: 437.4688 Elemental Analysis: C, 60.40; H, 3.92; F, 8.69; N, 16.01; O, 3.66; S, 7.33
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BAL4815; ; BAL-4815; BAL 4815; RO 0094815; RO-0094815; RO0094815; Isavuconazole; trade name Cresemba. Chemical Name: 4-(2-((2R, 3R)-3-(2, 5-difluorophenyl)-3-hydroxy-4-(1H-1, 2, 4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile InChi Key: DDFOUSQFMYRUQK-RCDICMHDSA-N InChi Code: InChI=1S/C22H17F2N5OS/c1-14(21-28-20(10-31-21)16-4-2-15(9-25)3-5-16)22(30, 11-29-13-26-12-27-29)18-8-17(23)6-7-19(18)24/h2-8, 10, 12-14, 30H, 11H2, 1H3/t14-, 22+/m0/s1 SMILES Code: N#CC1=CC=C(C2=CSC([CH]([C](O)(C3=CC(F)=CC=C3F)CN4N=CN=C4)C)=N2)C=C1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 500mg

available

Delivery expected until 9/6/2024

Express Delivery: Save 15 days

Compare

Add to wishlist

Recommend by mail