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vitamin-k4

vitamin-k4

Item no.	V5302-10g
Manufacturer	InvivoChem LLC
CASRN	573-20-6
Amount	10g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V5302CAS #:573-20-6Purity >=98% Description: Vitamin K4 (also known as Acetomenaphthone), a synthetic hydrophilic menadione compound, is clinically used as hemostasis medicine. Vitamin K4 also has anticancer activities by inducing tumor cytotoxicity in human prostate carcinoma PC-3 cells via the mitochondria-related apoptotic pathway. VK4 dose-dependently inhibited cell proliferation in PC-3 cells with an IC50 value of about 20.94 microM. Hoechst 33258 Staining results showed that VK4 caused DNA fragmentation in PC-3 cells. PI staining results indicated that VK4-induced PC-3 cell cycle arrest at the S phase. Further mechanistic studies revealed that VK4-mediated induction of apoptosis in PC-3 cell is associated with disruption of mitochondrial membrane potential, down-regulation of Bcl-2, and up-regulation of Bax, release of cytochrome c from mitochondria, and activation of caspase-3 and PARR Thus, VK4 might be useful in prostate cancer chemotherapy. References: Pharmazie. 2013 Jun; 68(6):442-8.
	Name: Vitamin K4 (VK4) CAS#: 573-20-6 Chemical Formula: C15H14O4 Exact Mass: 258.0892 Molecular Weight: 258.27 Elemental Analysis: C, 69.76; H, 5.46; O, 24.78
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: Vitamin K4 (VK4); Acetomenaphthone; NSC 403062; NSC-403062; NSC403062 Chemical Name: 1, 4-Naphthalenediol, 2-methyl-, diacetate InChi Key: RYWSYCQQUDFMAU-UHFFFAOYSA-N InChi Code: InChI=1S/C15H14O4/c1-9-8-14(18-10(2)16)12-6-4-5-7-13(12)15(9)19-11(3)17/h4-8H, 1-3H3 SMILES Code: CC1=CC(OC(C)=O)=C2C=CC=CC2=C1OC(C)=O

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Amount: 10g

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Delivery expected until 9/6/2024