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phortress-hcl

phortress-hcl

Item no.	V5196-25mg
Manufacturer	InvivoChem LLC
CASRN	328087-38-3
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V5196CAS #:328087-38-3Purity >=98% Description: Phortress HCl (also known as NSC-710305) is a novel and potent apoptosis stimulant and also a P450 CYP1A1-activated antitumor prodrug with the potential for the treatment of solid tumours. Phortress had no effect on HUVEC and MRCV cell proliferation and survival. Unlike paclitaxel and fumagillin, Phortress did not inhibit endothelial tube differentiation. Phortress therefore exhibits no in vitro anti-angiogenic activity. As expected, Phortress was cytotoxic to MCF7 breast cancer cells, but unexpectedly, Phortress was also potent against colorectal cancer cells in clonogenic survival and cell growth (growth curves but not MTS assay) end-points. References: Toxicol Sci. 2013 Feb; 131(2):470-9.; Br J Cancer. 2003 Feb 24; 88(4):599-605. Related CAS: 741241-36-1 (free) 328087-38-3 (HCl)
	Name: Phortress CAS#: 328087-38-3 (HCl) Chemical Formula: C20H25Cl2FN4OS Exact Mass: Molecular Weight: 459.4054 Elemental Analysis: C, 52.29; H, 5.49; Cl, 15.43; F, 4.14; N, 12.20; O, 3.48; S, 6.98
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: NSC-710305; NSC-710305; NSC-710305; 5F-DF-203 L-lysinamide; 5FDF 203 Llysinamide Chemical Name: (S)-2, 6-diamino-N-(4-(5-fluorobenzo[d]thiazol-2-yl)-2-methylphenyl)hexanamide dihydrochloride InChi Key: QZSMNTOCJVVFEU-CKUXDGONSA-N InChi Code: InChI=1S/C20H23FN4OS.2ClH/c1-12-10-13(20-25-17-11-14(21)6-8-18(17)27-20)5-7-16(12)24-19(26)15(23)4-2-3-9-22; ; /h5-8, 10-11, 15H, 2-4, 9, 22-23H2, 1H3, (H, 24, 26); 2*1H/t15-; ; /m0../s1 SMILES Code: NCCCC[CH](N)C(NC1=CC=C(C2=NC(C=C(F)C=C3)=C3S2)C=C1C)=O.Cl.Cl

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Amount: 25mg

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