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Description: Lersivirine (formerly UK-453061) is a novel next-generation and potent non-nucleoside reverse transcriptase inhibitor (NNRTI) with IC50 of 119 nM and a unique resistance profile. It exhibits potent antiretroviral activity against wild-type human immunodeficiency virus and clinically relevant NNRTI-resistant strains. Lersivirine was under development for HIV infection therapy. It binds reverse transcriptase in a distinct way leading to a unique resistance profile. In February 2013, ViiV Healthcare announced the development of lersivirine was disconinued.
References: Bioorg Med Chem Lett. 2009 Oct 15; 19(20):5857-60.
Related CAS: 147362-57-0 (Loviride); 16837-52-8 (Oxymatrine?
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