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alsterpaullone

alsterpaullone

Item no.	V5083-25mg
Manufacturer	InvivoChem LLC
CASRN	237430-03-4
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V5083CAS #:237430-03-4Purity >=98% Description: Alsterpaullone (also known as 9-Nitropaullone and NSC-705701; NSC 705701) is a novel and potent ATP-competitive cyclin-dependent kinases (CDK) inhibitor with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone (9-Nitropaullone; NSC 705701) also competes with ATP for binding to glycogen synthase kinase-3 alpha/beta (GSK-3alpha/GSK-3beta) with IC50s of both 4 nM. Alsterpaullone (9-Nitropaullone; NSC 705701) has antitumor activity, and possesses potential for the treatment of neurodegenerative and proliferative disorders. Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone mediated toxicity in HeLa Cells through Apoptosis-Inducing Effect. References: Mol Carcinog. 2003 Apr; 36(4):183-94. Related CAS #: 237430-03-4 (); 852529-97-0 (Alsterpaullone, 2-Cyanoethyl)
	Name: Alsterpaullone CAS#: 237430-03-4 Chemical Formula: C16H11N3O3 Exact Mass: 293.08 Molecular Weight: 293.282 Elemental Analysis: C, 65.53; H, 3.78; N, 14.33; O, 16.37
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: 9-Nitropaullone; NSC-705701; NSC 705701; NSC705701; Alsterpaullone IUPAC/Chemical Name: 7, 12-dihydro-9-nitro-indolo[3, 2-d][1]benzazepin-6(5H)-one InChi Key: OLUKILHGKRVDCT-UHFFFAOYSA-N InChi Code: InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7, 18H, 8H2, (H, 17, 20) SMILES Code: O=C1NC2=CC=CC=C2C(NC3=C4C=C([N+]([O-])=O)C=C3)=C4C1

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Amount: 25mg

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