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tg-100801-hcl

tg-100801-hcl

Item no.	V5007-50mg
Manufacturer	InvivoChem LLC
CASRN	867331-82-6 (free base)
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V5007CAS #:867331-82-6 (free base)Purity >=98% Description:TG 100801, an ester prodrug of TG 100572, is a novel and potent dual inhibitor of VEGFr2 and the Src family (Src and YES) kinases in development to treat age-related macular degeneration.As a topically administered therapeutic candidate and a multi-targeted kinase inhibitor, it inhibits receptor tyrosine kinases and Src kinases with IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRbeta, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively. References: J Med Chem. 2008 Mar 27; 51(6):1546-59. Related CAS #: 867331-82-6 (free base); 1018069-81-2 (HCl)
	Name: TG100801 CAS#: 867331-82-6 (free base) Chemical Formula: C33H30ClN5O3 Exact Mass: 579.2037 Molecular Weight: 580.085 Elemental Analysis: C, 68.33; H, 5.21; Cl, 6.11; N, 12.07; O, 8.27
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: TG100801; TG-100801; TG 100801. IUPAC/Chemical Name: 4-chloro-3-(5-methyl-3-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)benzo[e][1, 2, 4]triazin-7-yl)phenyl benzoate InChi Key: JMGXJHWTVBGOKG-UHFFFAOYSA-N InChi Code: InChI=1S/C33H30ClN5O3/c1-22-19-24(28-21-27(13-14-29(28)34)42-32(40)23-7-3-2-4-8-23)20-30-31(22)36-33(38-37-30)35-25-9-11-26(12-10-25)41-18-17-39-15-5-6-16-39/h2-4, 7-14, 19-21H, 5-6, 15-18H2, 1H3, (H, 35, 36, 38) SMILES Code: CC1=C2C(=CC(=C1)C3=C(C=CC(=C3)OC(=O)C4=CC=CC=C4)Cl)N=NC(=N2)NC5=CC=C(C=C5)OCCN6CCCC6

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