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sr12813

sr12813

Item no.	V4949-50mg
Manufacturer	InvivoChem LLC
CASRN	126411-39-0
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4949CAS #:126411-39-0Purity >=98% Description: SR12813, a 1, 1-bisphosphonate ester, is a novel and potent pan retinoid X receptor (RXR) agonist that is devoid of any RAR activity. SR-12813 exhibits hypocholesterolemic activity by enhancing the degradation of HMG-CoA reductase in various animal models. SR-12813 is also a high affinity ligand for human and rabbit pregnane X receptors (Kd = 41 nM; EC50 = 137 nM for hPXR in vitro) and can induce cytochrome P450 3A expression in human and rabbit hepatocytes. References: PLoS One. 2014 Nov 26; 9(11):e112632.
	Formal Name: P, P'-[[3, 5-bis(1, 1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid P, P, P', P'-tetraethyl ester CAS Number: 126411-39-0 Synonyms: GW 485801 Molecular Formula: C24H42O7P2 Formula Weight: 504.5 SMILES: OC1=C(C(C)(C)C)C=C(/C=C(P(OCC)(OCC)=O)/P(OCC)(OCC)=O)C=C1C(C)(C)C InChi Code: InChI=1S/C24H42O7P2/c1-11-28-32(26, 29-12-2)21(33(27, 30-13-3)31-14-4)17-18-15-19(23(5, 6)7)22(25)20(16-18)24(8, 9)10/h15-17, 25H, 11-14H2, 1-10H3 InChi Key: YQLJDECYQDRSBI-UHFFFAOYSA-N
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	GW 485801; GW-485801; GW485801; SR 12813; SR-12813; SR12813

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Amount: 50mg

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