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solabegron-hc1

solabegron-hc1

Item no.	V4945-100mg
Manufacturer	InvivoChem LLC
CASRN	451470-34-1 (HCl)
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4945CAS #:451470-34-1 (HCl)Purity >=98% Description: Solabegron (formerly also known as GW 427353; GW-427353; GW-427, 353) is a novel, potent and selective agonist for the beta3 adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human beta3-AR, with an EC50 value of 22 nM. It is being investigated for the treatment of overactive bladder and irritable bowel syndrome. It has been shown to produce visceral analgesia by releasing somatostatin from adipocytes. Solabegron decreases excitability of human enteric neurons via release of somatostatin. Solabegron evokes bladder relaxation and increases micturition reflex threshold in the dog. References: J Pharmacol Exp Ther. 2007 Oct; 323(1):202-9.; J Urol. 2013 Oct; 190(4):1173-80. Related CAS #: 451470-34-1 (HCl); 252920-94-8 (free base)
	Name: Solabegron HCl CAS#: 451470-34-1 (HCl) Chemical Formula: C23H24Cl2N2O3 Molecular Weight: 447.356 Elemental Analysis: C, 61.75; H, 5.41; Cl, 15.85; N, 6.26; O, 10.73
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: GW-427353; GW 427353; GW427353; GW-427, 353; GW 427, 353; GW427, 353; Solabegron HC1; Solabegron hydrochloride. IUPAC/Chemical Name: (R)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-[1, 1'-biphenyl]-3-carboxylic acid hydrochloride InChi Key: PMXCGBVBIRYFPR-FTBISJDPSA-N InChi Code: InChI=1S/C23H23ClN2O3.ClH/c24-20-8-2-6-18(13-20)22(27)15-25-10-11-26-21-9-3-5-17(14-21)16-4-1-7-19(12-16)23(28)29; /h1-9, 12-14, 22, 25-27H, 10-11, 15H2, (H, 28, 29); 1H/t22-; /m0./s1 SMILES Code: O=C(C1=CC(C2=CC=CC(NCCNC[CH](C3=CC=CC(Cl)=C3)O)=C2)=CC=C1)O.[H]Cl

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Amount: 100mg

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