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gw627368

gw627368

Item no.	V4931-10mg
Manufacturer	InvivoChem LLC
CASRN	439288-66-1
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	439288-66-1
Available
Description	InvivoChem Cat #:V4931CAS #:439288-66-1Purity >=98% Description: GW627368 (also known as GW627368X) is a novel, orally bioavailable, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity and with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively. GW627368X showed significant tumor regression characterized by tumor reduction and induction of apoptosis. Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma. GW627368X will be a valuable tool to explore the role of the prostanoid EP4 receptor in many physiological and pathological settings. References: Br J Pharmacol. 2006 Jun; 148(3):326-39.; Cancer Biol Ther. 2015; 16(6):922-32.
	Name: GW-627368; GW627368X CAS#: 439288-66-1 Chemical Formula: C30H28N2O6S Exact Mass: 544.16681 Molecular Weight: 544.62 Elemental Analysis: C, 66.16; H, 5.18; N, 5.14; O, 17.63; S, 5.89
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: GW627368X; GW 627368X; GW-627368X; GW627368; GW 627368; GW-627368. IUPAC/Chemical Name: 2-(4-(4, 9-diethoxy-1-oxo-1, 3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl)-N-(phenylsulfonyl)acetamide InChi Key: XREWXJVMYAXCJV-UHFFFAOYSA-N InChi Code: InChI=1S/C30H28N2O6S/c1-3-37-28-23-12-8-9-13-24(23)29(38-4-2)27-25(28)19-32(30(27)34)21-16-14-20(15-17-21)18-26(33)31-39(35, 36)22-10-6-5-7-11-22/h5-17H, 3-4, 18-19H2, 1-2H3, (H, 31, 33) SMILES Code: O=C(NS(=O)(C1=CC=CC=C1)=O)CC2=CC=C(N(CC3=C4C(OCC)=C(C=CC=C5)C5=C3OCC)C4=O)C=C2

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Amount: 10mg

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