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gw843682x

gw843682x

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	10mg
Item no.	V4918-10mg
CASRN	660868-91-7
eClass 6.1	32160405
eClass 9.0	32160490
Available
Alias	660868-91-7
Description	InvivoChem Cat #:V4918CAS #:660868-91-7Purity >=98% Description: GW843682X is a novel, potent, selective, ATP-competitive inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) with IC50s of 2.2 nM and 9.1 nM, respectively. It is more than 100-fold selective against ?30 other kinases. GW843682X inhibited the proliferation and induced apoptosis of 5-8F cells in a dose-dependent manner (IC50=62.5-125nmol/L). GW843682X exhibited remarkable cytotoxic effects on nasopharyngeal carcinoma 5-8F cells by down-regulating IAP gene expression, suggesting that GW843682X may become a novel therapeutic agent for nasopharyngeal carcinoma. References: Mol Cancer Ther. 2007 Feb; 6(2):450-9. Epub 2007 Jan 31.; Eur J Pharmacol. 2008 Sep 4; 591(1-3):102-5.; Leukemia. 2009 Sep; 23(9):1564-76.
	Name: GW843682X CAS#: 660868-91-7 Chemical Formula: C22H18F3N3O4S Exact Mass: 477.097 Molecular Weight: 477.4582 Elemental Analysis: C, 55.34; H, 3.80; F, 11.94; N, 8.80; O, 13.40; S, 6.71
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: GW843682X; GW 843682X; GW-843682X. IUPAC/Chemical Name: 5-(5, 6-dimethoxybenzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]thiophene-2-carboxamide InChi Key: JSKUWFIZUALZLX-UHFFFAOYSA-N InChi Code: InChI=1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23, 24)25/h3-9, 11H, 10H2, 1-2H3, (H2, 26, 29) SMILES Code: O=C(C1=C(OCC2=CC=CC=C2C(F)(F)F)C=C(N3C4=CC(OC)=C(OC)C=C4N=C3)S1)N

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