Description |
InvivoChem Cat #:V4888CAS #:1638288-31-9 Purity >=98%Description: Gemcitabine monophosphate disodium (GemMP) is a monophosphate analog of Gemcitabine (formerly also known as LY-188011, NSC 613327; dFdC; dFdCyd; gemcitabine; trade name: Gemzar), an antimetabolite anticancer drug, which is a potent DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis. References: Adv Funct Mater. 2014 Nov 12; 24(42):6601-6611. Related CAS : 95058-81-4 (free base); 122111-03-9 (HCl); 210829-30-4 Gemcitabine elaidate, also known as CO-101 and CP-4126, is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC); 116371-67-6 (Gemcitabine monophosphate free acid); 840506-29-8 Acelarin (NUC-1031) is a ProTide transformation and enhancement of the widely-used nucleoside analogue, gemcitabine; 892128-60-8 (LY2334737, an orally bioavailable prodrug of gemcitabine) |
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Name: Gemcitabine monophosphate disodium salt CAS#: 1638288-31-9 (disodium salt); 116371-67-6 (free acid) Chemical Formula: C9H12F2N3Na2O8P Exact Mass: Molecular Weight: 405.15811 Elemental Analysis: C, 26.68; H, 2.99; F, 9.38; N, 10.37; Na, 11.35; O, 31.59; P, 7.64 |
Technical Information |
Synonym: GemMP; Gemcitabine monophosphate disodium salt monohydrate; Gemcitabine monophosphate disodium; IUPAC/Chemical Name: sodium ((2R, 3R, 5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4, 4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl phosphate hydrate InChi Key: YOWQXAMQHWESCE-RBECAVKOSA-L InChi Code: InChI=1S/C9H12F2N3O7P.2Na.H2O/c10-9(11)6(15)4(3-20-22(17, 18)19)21-7(9)14-2-1-5(12)13-8(14)16; ; ; /h1-2, 4, 6-7, 15H, 3H2, (H2, 12, 13, 16)(H2, 17, 18, 19); ; ; 1H2/q; 2*+1; /p-2/t4-, 6-, 7-; ; ; /m1.../s1 SMILES Code: O=C1N=C(N)C=CN1[CH]2O[CH](COP(O[Na])(O[Na])=O)[CH](O)C2(F)F.O |