Description |
InvivoChem Cat #:V4875CAS #:1019889-35-0 (lactate)Purity >=98%Description: Onalespib (formerly also known as AT13387) is a novel, potent, selective, synthetic, orally bioavailable, small-molecule Hsp90 inhibitor with IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. AT13387 selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability and degradation of many oncogenic signaling proteins. References: Cancer Sci. 2012 Mar; 103(3):522-7. Related CAS : 912999-49-6 (free base)
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![Onalespib lactate]()
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Name: Onalespib lactate CAS#: 1019889-35-0 (lactate) Chemical Formula: C27H37N3O6 Exact Mass: Molecular Weight: 499.608 Elemental Analysis: C, 64.91; H, 7.47; N, 8.41; O, 19.21 |
Technical Information |
Synonym: Onalespib lactate; AT-13387 lactate; ATI-13387A; ATI-13387AU; ATI-13387; ATI 13387; ATI13387. IUPAC/Chemical Name: (2, 4-dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone (S)-2-hydroxypropanoate InChi Key: VYRWEWHOAMGLLW-WNQIDUERSA-N InChi Code: InChI=1S/C24H31N3O3.C3H6O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26; 1-2(4)3(5)6/h4-5, 10-12, 16, 28-29H, 6-9, 13-15H2, 1-3H3; 2, 4H, 1H3, (H, 5, 6)/t; 2-/m.0/s1 SMILES Code: C[CH](O)C(O)=O.O=C(N1CC2=C(C=C(CN3CCN(C)CC3)C=C2)C1)C4=CC(C(C)C)=C(O)C=C4O |