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Description: PD-159020 is a novel, potent, and non-selective indole non-peptide antagonist of ETA/ETB (Endothelin) with IC50s of 30 and 50 nM for hETA and hETB, respectively. Endothelin-1 is a potent vasoconstrictor that is thought to be involved in many human disease states.
References: Bioorganic & Medicinal Chemistry Letters. Volume 6, Issue 9, 7 May 1996, Pages 1061-1066
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