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bms-986165

bms-986165

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	25mg
Item no.	V4752-25mg
CASRN	1609392-27-9
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V4752CAS #:1609392-27-9Purity >=98% Description: Deucravacitinib (BMS986165; Tyk2-IN-4) is a novel, highly potent, orally bioavailable, selective and allosteric inhibitor of TYK2 (tyrosine kinase 2) in Phase 3 clinical studies across multiple immune-mediated diseases such as psoriatic arthritis, lupus and inflammatory bowel disease. BMS-986165 is able to block Il-12, IL-23 and type I interferon signaling. BMS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional responses (IC50 range 2-14 nM). References: WO2018183649A1.; WO2018183656A1.; WO2014074661A1.
	Name: BMS-986165 CAS#: 1609392-27-9 Chemical Formula: C20H19D3N8O3 Exact Mass: 425.2003 Molecular Weight: 425.4673 Elemental Analysis: C, 56.46; H, 5.92; N, 26.34; O, 11.28
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: Deucravacitinib; BMS-986165; BMS 986165; BMS986165 Chemical Name: 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1, 2, 4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide SMILES Code: O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC(C4=NN(C)C=N4)=C3OC)NC([2H])([2H])[2H]

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Amount: 25mg

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Delivery expected until 8/2/2024

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