bi8626

Item no.	V4713-10mg
Manufacturer	InvivoChem LLC
CASRN	1875036-75-1
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4713CAS #:1875036-75-1Purity >=98% Description: BI8626 is a novel, potent and specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 0.9 uM. Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARF-BP1, MULE) associates with both MYC and the MYC-associated protein MIZ1. References: EMBO Mol Med. 2014 Dec; 6(12):1525-41.
	Name: BI-8626 CAS#: 1875036-75-1 Chemical Formula: C25H28N8 Exact Mass: 440.2437 Molecular Weight: 440.56 Elemental Analysis: C, 68.16; H, 6.41; N, 25.44
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BI8626; BI 8626; BI-8626 IUPAC/Chemical Name: N-(3-(Aminomethyl)benzyl)-8-(4-benzylpiperazin-1-yl)pyrimido[5, 4-d]pyrimidin-4-amine InChi Key: DZDNGSNKWIORRZ-UHFFFAOYSA-N InChi Code: InChI=1S/C25H28N8/c26-14-20-7-4-8-21(13-20)15-27-24-22-23(29-17-30-24)25(31-18-28-22)33-11-9-32(10-12-33)16-19-5-2-1-3-6-19/h1-8, 13, 17-18H, 9-12, 14-16, 26H2, (H, 27, 29, 30) SMILES Code: NCC1=CC(CNC2=C(N=CN=C3N4CCN(CC5=CC=CC=C5)CC4)C3=NC=N2)=CC=C1

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