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bi-882370

bi-882370

Item no.	V4710-25mg
Manufacturer	InvivoChem LLC
CASRN	1392429-79-6
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4710CAS #:1392429-79-6Purity >=98% Description: BI-882370 (BI 882370), structurally similar to vermurafenib, is a novel, highly potent and selective BRAF inhibitor that binds to the ATP site of the RAF kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases with IC50s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases. BI 882370 inhibits proliferation of human BRAF-mutant melanoma cells with 100x higher potency (1-10 nmol/L) than vemurafenib. References: Mol Cancer Ther. 2016 Mar; 15(3):354-65.
	Name: BI 882370 CAS#: 1392429-79-6 Chemical Formula: C28H33F2N7O2S Exact Mass: 569.2385 Molecular Weight: 569.68 Elemental Analysis: C, 59.03; H, 5.84; F, 6.67; N, 17.21; O, 5.62; S, 5.63
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BI 882370; BI-882370; BI882370. IUPAC/Chemical Name: N-(3-(5-((1-ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3, 2-b]pyridin-1-yl)-2, 4-difluorophenyl)propane-1-sulfonamide InChi Key: GAIOPWBQKZMUNO-UHFFFAOYSA-N InChi Code: InChI=1S/C15H15FN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17, 23)24/h3-7H, 1-2H3, (H, 18, 20)(H2, 17, 23, 24)(H, 19, 21, 22) SMILES Code: O=S(C1=CC=CC(NC2=NC=C(F)C(C3=C(C)N=C(NC)S3)=N2)=C1)(N)=O

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Amount: 25mg

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Delivery expected until 9/6/2024

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