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bi-224436

bi-224436

Item no.	V4700-10mg
Manufacturer	InvivoChem LLC
CASRN	1155419-89-8
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4700CAS #:1155419-89-8Purity >=98% Description: BI-224436, an investigational new drug under development for the treatment of HIV infection, is the first non-catalytic site integrase inhibitor (NCINI) with EC50 values of less than 15 nM against different HIV-1 laboratory strains.. It inhibits HIV replication via binding to a conserved allosteric pocket of the HIV integrase enzyme. This makes the drug distinct in mechanism of action compared to raltegravir and elvitegravir, which bind at the catalytic site. References: Antimicrob Agents Chemother. 2014 Jun; 58(6):3233-44.
	Name: BI-224436 CAS#: 1155419-89-8 Chemical Formula: C24H25NO4 Exact Mass: 391.1784 Molecular Weight: 391.467 Elemental Analysis: C, 73.64; H, 6.44; N, 3.58; O, 16.35
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BI-224436; BI 224436; BI224436. IUPAC/Chemical Name: (2S)-[4-(3, 4-Dihydro-2H-chromen-6-yl)-3-quinolinyl][(2-methyl-2-propanyl)oxy]acetic acid InChi Key: DMWVBLFYARRIDL-QFIPXVFZSA-N InChi Code: InChI=1S/C24H25NO4/c1-24(2, 3)29-22(23(26)27)18-14-25-19-9-5-4-8-17(19)21(18)16-10-11-20-15(13-16)7-6-12-28-20/h4-5, 8-11, 13-14, 22H, 6-7, 12H2, 1-3H3, (H, 26, 27)/t22-/m0/s1 SMILES Code: O=C(O)[CH](C1=C(C2=CC(CCCO3)=C3C=C2)C4=CC=CC=C4N=C1)OC(C)(C)C

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Amount: 10mg

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Delivery expected until 9/6/2024

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