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pranlukast

pranlukast

Item no.	V4685-1g
Manufacturer	InvivoChem LLC
CASRN	103177-37-3
Amount	1g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	103177-37-3
Available
Description	InvivoChem Cat #:V4685CAS #:103177-37-3Purity >=98% Description: Pranlukast is a potent, selective and competitive antagonist of cysteinyl leukotriene receptor-1 (CysLT1) Pranlukast with Kis of 0.63+/-0.11, 0.99+/-0.19, and 5640+/-680 nM for inhibiting 3HLTE4, 3HLTD4, and 3HLTC4 bindings to lung membranes, respectively.. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G protein-coupled receptors, CysLT1 and CysLT2. References: Acta Pharmacol Sin. 2012 Dec; 33(12):1511-7. Related CAS : 103177-37-3; 150821-03-7 (Pranlukast hemihydrate)
	Name: Pranlukast CAS#: 103177-37-3 Chemical Formula: C27H23N5O4 Exact Mass: 481.175 Molecular Weight: 481.5 Elemental Analysis: C, 67.35; H, 4.81; N, 14.54; O, 13.29
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: Ono-1078; ONO 1078; ONO-1078; ONO-RS 411; ONO-RS-411; SB 205312; IUPAC/Chemical Name: N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide InChi Key: NBQKINXMPLXUET-UHFFFAOYSA-N InChi Code: InChI=1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3, 6-8, 10-15, 17H, 4-5, 9, 16H2, (H, 28, 34)(H, 29, 30, 31, 32) SMILES Code: C1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)C(=O)NC3=CC=CC4=C3OC(=CC4=O)C5=NNN=N5

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