siremadlin

InvivoChem Cat #:V4660CAS #:1448867-41-1Purity >=98%

Description: Siremadlin (formerly also known as NVP-HDM201 and HDM201) is a novel, potent, highly specific and orally bioavailable MDM-2/p53 inhibitor. As a human double minute 2 homolog (HDM2) inhibitor, it has potential antineoplastic activity. Siremadlin inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. HDM2, a zinc finger protein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival.

References: Proc Natl Acad Sci U S A. 2017 Mar 21; 114(12):3151-3156.; Bioorg Med Chem Lett. 2016 Oct 1; 26(19):4837-41.

Related CAS : 1448867-41-1; 1448867-42-2 (Siremadlin R Enantiomer)

-20C for 3 years in powder form

Synonym: HDM201; HDM 201; HDM-201; NVP HDM 201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201.
IUPAC/Chemical Name: (6S)-5-(5-chloro-1, 2-dihydro-1-methyl-2-oxo-3-pyridinyl)-6-(4-chlorophenyl)-2-(2, 4-dimethoxy-5-pyrimidinyl)-5, 6-dihydro-1-(1-methylethyl)-Pyrrolo[3, 4-d]imidazol-4(1H)-one
InChi Key: AGBSXNCBIWWLHD-FQEVSTJZSA-N
InChi Code: InChI=1S/C26H24Cl2N6O4/c1-13(2)33-21-19(30-22(33)17-11-29-26(38-5)31-23(17)37-4)25(36)34(18-10-16(28)12-32(3)24(18)35)20(21)14-6-8-15(27)9-7-14/h6-13, 20H, 1-5H3/t20-/m0/s1
SMILES Code: O=C1N(C2=CC(Cl)=CN(C)C2=O)[CH](C3=CC=C(Cl)C=C3)C4=C1N=C(C5=CN=C(OC)N=C5OC)N4C(C)C