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Description: Mc-MMAE is a novel protective group for MMAE (maleimidocaproyl)-conjugated monomethyl auristatin E, which is a highly potent mitotic/tubulin inhibitor, and is a toxin payload/warhead in antibody drug conjugate (ADC). Effective antibody-drug conjugates (ADC) combine high drug-linker stability in circulation and efficient intratumoral release of drug. Conjugation of monomethyl auristatin E (MMAE) to the anti-CD30 monoclonal antibody (mAb), cAC10, produced a selective and potent ADC against CD30(+) anaplastic large cell lymphoma and Hodgkin's disease models.
References: Clin Cancer Res. 2005 Jan 15; 11(2 Pt 1):843-52.
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