pun-30119

InvivoChem Cat #:V4648CAS #:1801530-11-9Purity >=98%

Description: PUN30119 s a novel, potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system Xc- and an activator of ferroptosis. It is a system xc- and inducer of ferroptosis potentially suitable for in vivo applications.

References: Cell Chem Biol. 2019 Jan 31. pii: S2451-9456(19)30030-3.; Bioorg Med Chem Lett. 2015 Nov 1; 25(21):4787-4792.

-20C for 3 years in powder form

Synonym: PUN30119; PUN-30119; PUN 30119; Imidazole ketone erastin; IKE; Ferroptosis inducer IKE;
IUPAC/Chemical Name: 3-(5-(2-(1H-imidazol-1-yl)acetyl)-2-isopropoxyphenyl)-2-((4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one
InChi Key: PSPXJPWGVFNGQI-UHFFFAOYSA-N
InChi Code: InChI=1S/C35H35ClN6O5/c1-24(2)47-32-12-7-25(31(43)20-40-14-13-37-23-40)19-30(32)42-33(38-29-6-4-3-5-28(29)35(42)45)21-39-15-17-41(18-16-39)34(44)22-46-27-10-8-26(36)9-11-27/h3-14, 19, 23-24H, 15-18, 20-22H2, 1-2H3
SMILES Code: O=C1N(C2=CC(C(CN3C=NC=C3)=O)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=C1C=CC=C6