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gsk2110183-hcl

gsk2110183-hcl

Item no.	V4633-500mg
Manufacturer	InvivoChem LLC
CASRN	2070009-64-0
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4633CAS #:2070009-64-0Purity >=98% Description: GSK2110183 HCl, an analog of Afuresertib, is a potent, orally bioavailable and ATP-competitive Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. GSK2110183 is an inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. References: Cancer Chemother Pharmacol. 2015 Jan; 75(1):183-9; Blood. 2014 Oct 2; 124(14):2162-3. Related CAS #: 2070009-64-0 (GSK2110183 HCl); 1047634-63-8 (GSK2110183); 1047644-62-1 (Afuresertib / GSK2110183C); 1047645-82-8 (Afuresertib HCl / GSK2110183B)
Molecular Weight (MW)	481.77
Formula	C18H17Cl3F2N4OS
CAS No.	2070009-64-0 (GSK2110183 HCl); 1047634-63-8 (GSK211018); 1047644-62-1 (Afuresertib / GSK2110183B); 1047645-82-8 (Afuresertib HCl)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 36 mg/mL
	Water: N/A
	Ethanol: N/A
SMILES	O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)S1)N[CH](CC3=CC=C(F)C(F)=C3)CN.[H]Cl
Synonyms/Chemical Name	GSK2110183; GSK-2110183; GSK 2110183; Afuresertib-F; GSK-2110183 analog; GSK2110183 analog; GSK 2110183 analog; Afuresertib-F HCl; Afuresertib-F hydrochloride; N-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)thiophene-2-carboxamide;

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Amount: 500mg

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Delivery expected until 9/6/2024

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