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tonabersat

tonabersat

Item no.	V4626-50mg
Manufacturer	InvivoChem LLC
CASRN	175013-84-0
Amount	50mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4626CAS #:175013-84-0Purity >=98% Description: Tonabersat (also known as SB-220453), a novel benzopyran derivative, is a novel and potent gap-junction modulator used for the prevention of migraine. Tonabersatinhibits cortical spreading depression (CSD) and therefore might be able to inhibit the early migraine mechanisms. Treatment with either Tonabersat (10 mg/kg) or Meclofenamate (20 mg/kg) as single agents significantly inhibit progression of metastatic lesions. Addition of carboplatin to either agent profoundly inhibits brain metastasis. References: Neurotherapeutics. 2017 May 30.
	Name: Tonabersat CAS#: 175013-84-0 Chemical Formula: C20H19ClFNO4 Exact Mass: 391.0987 Molecular Weight: 391.8234 Elemental Analysis: C, 61.31; H, 4.89; Cl, 9.05; F, 4.85; N, 3.57; O, 16.33
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: SB-220453; SB 220453; SB220453 Chemical Name: N-((3S, 4S)-6-Acetyl-3-hydroxy-2, 2-dimethylchroman-4-yl)-3-chloro-4-fluorobenzamide InChi Key: XLIIRNOPGJTBJD-ROUUACIJSA-N InChi Code: InChI=1S/C20H19ClFNO4/c1-10(24)11-5-7-16-13(8-11)17(18(25)20(2, 3)27-16)23-19(26)12-4-6-15(22)14(21)9-12/h4-9, 17-18, 25H, 1-3H3, (H, 23, 26)/t17-, 18-/m0/s1 SMILES Code: O=C(N[CH]1[CH](O)C(C)(C)OC2=C1C=C(C(C)=O)C=C2)C3=CC=C(F)C(Cl)=C3

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Amount: 50mg

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