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upadacitinib

upadacitinib

Item no.	V4509-500mg
Manufacturer	InvivoChem LLC
CASRN	1310726-60-3 (free base)
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4509CAS #:1310726-60-3 (free base)Purity >=98% Description: Upadacitinib (also known as ABT-494) is a novel, potent and selective Janus kinase (JAK) 1 inhibitor with an IC50 of 43 nM, it is being developed for the treatment of several autoimmune disorders, e.g. rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling. References: BioDrugs. 2016 Oct; 30(5):407-419. Related CAS : 1310726-60-3 (free base); 1607431-21-9 (tartarte)
	Name: Upadacitinib CAS#: 1310726-60-3 (free base) Chemical Formula: C17H19F3N6O Exact Mass: 380.1572 Molecular Weight: 380.3752 Elemental Analysis: C, 53.68; H, 5.04; F, 14.98; N, 22.09; O, 4.21
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: ABT-494, ABT 494, ABT494 IUPAC/Chemical Name: (3S, 4R)-3-ethyl-4-(3H-imidazo[1, 2-a]pyrrolo[2, 3-e]pyrazin-8-yl)-N-(2, 2, 2-trifluoroethyl)pyrrolidine-1-carboxamide InChi Key: WYQFJHHDOKWSHR-MNOVXSKESA-N InChi Code: InChI=1S/C17H19F3N6O/c1-2-10-7-25(16(27)24-9-17(18, 19)20)8-11(10)13-5-22-14-6-23-15-12(26(13)14)3-4-21-15/h3-6, 10-11, 21H, 2, 7-9H2, 1H3, (H, 24, 27)/t10-, 11+/m1/s1 SMILES Code: O=C(N1C[CH](CC)[CH](C2=CN=C3C=NC(NC=C4)=C4N32)C1)NCC(F)(F)F

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Amount: 500mg

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Delivery expected until 10/4/2024

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