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ku-0060648

ku-0060648

Item no.	V4346-5mg
Manufacturer	InvivoChem LLC
CASRN	881375-00-4
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	881375-00-4
Available
Description	InvivoChem Cat #:V4346CAS #:881375-00-4 Purity >=98% Description: KU0060648 is a novel, potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) with IC50 of 8.6 nM and with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases. KU-0060648 enhances HDR efficiency and attenuates NHEJ frequency. KU-0060648 is also considered as a dual inhibitor of DNA-PK and PI-3K. KU-0060648 inhibited cellular DNA-PK autophosphorylation with IC(50) values of 0.019 umol/L (MCF7 cells) and 0.17 umol/L (SW620 cells), and PI-3K-mediated AKT phosphorylation with IC(50) values of 0.039 umol/L (MCF7 cells) and more than 10 umol/L (SW620 cells). KU-0060648 inhibits hepatocellular carcinoma cells through DNA-PKcs-dependent and DNA-PKcs-independent mechanisms. References: Oncotarget. 2016 Mar 29; 7(13):17047-59.
	Name: KU-0060648 CAS#: 881375-00-4 Chemical Formula: C33H34N4O4S Exact Mass: 582.23 Molecular Weight: 582.719 Elemental Analysis: C, 68.02; H, 5.88; N, 9.61; O, 10.98; S, 5.50
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: KU-0060648; KU 0060648; KU0060648. IUPAC/Chemical Name: 4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide InChi Key: AATCBLYHOUOCTO-UHFFFAOYSA-N InChi Code: InChI=1S/C33H34N4O4S/c1-2-35-12-14-36(15-13-35)21-29(39)34-26-11-10-23(33-31(26)25-6-3-4-9-28(25)42-33)22-7-5-8-24-27(38)20-30(41-32(22)24)37-16-18-40-19-17-37/h3-11, 20H, 2, 12-19, 21H2, 1H3, (H, 34, 39) SMILES Code: O=C1C=C(N2CCOCC2)OC3=C(C4=C5C(C6=CC=CC=C6S5)=C(NC(CN7CCN(CC7)CC)=O)C=C4)C=CC=C13

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Amount: 5mg

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Delivery expected until 10/4/2024

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