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pf-03654746

pf-03654746

Item no.	V4310-5mg
Manufacturer	InvivoChem LLC
CASRN	935840-31-6
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	935840-31-6
Available
Description	InvivoChem Cat #:V4310CAS #:935840-31-6 Purity >=98% Description: PF-03654746 is a novel, potent, specific and selective histamine H3 receptor antagonist with > 1000-fold selectivity for the H 3 receptor over the other histamine receptor subtypes. It is undergoing clinical trials for the treatment of ADHD, Tourette syndrome as well as potential anti-allergy applications. A previous clinical trial employing a nasal ragweed bolus after administration of PF-03654746 (an H 3 receptor antagonist with similar structure to PF-03654764) + fexofenadine demonstrated significantly reduced congestion, compared to placebo. However, PF-03654764 has never been tested in a randomized controlled trial of allergic rhinitis, or in the Environmental Exposure Unit (EEU), which better approximates real life by delivering the allergen in the ambient air. References: Xenobiotica. 2017 Feb; 47(2):119-126.
	Name: PF-03654746 CAS#: 935840-31-6 Chemical Formula: C18H24F2N2O Exact Mass: 322.1857 Molecular Weight: 322.4 Elemental Analysis: C, 67.06; H, 7.50; F, 11.79; N, 8.69; O, 4.96
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: PF-03654746; PF 03654746; PF03654746. IUPAC/Chemical Name: (1R, 3R)-N-Ethyl-3-fluoro-3-(3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl)cyclobutane-1-carboxamide InChi Key: SXMBKHYDZOCBMT-PPUGGXLSSA-N InChi Code: InChI=1S/C18H24F2N2O/c1-2-21-17(23)14-10-18(20, 11-14)15-6-5-13(16(19)9-15)12-22-7-3-4-8-22/h5-6, 9, 14H, 2-4, 7-8, 10-12H2, 1H3, (H, 21, 23)/t14-, 18- SMILES Code: O=C([CH]1C[C](C2=CC=C(CN3CCCC3)C(F)=C2)(F)C1)NCC

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Amount: 5mg

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Delivery expected until 9/6/2024

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