mk8033

Item no.	V4303-5mg
Manufacturer	InvivoChem LLC
CASRN	1001917-37-8
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1001917-37-8
Available
Description	InvivoChem Cat #:V4303CAS #:1001917-37-8 Purity >=98% Description: MK-8033 is a novel, potent, selective, ATP competitive small-molecule, dual inhibitor of c-Met/Ron (IC50=1 nM Wt c-Met) under investigation as a treatment for cancer. The design of MK-8033 was based on the desire to reduce time-dependent inhibition of CYP3A4 (TDI) by members of this structural class. A novel two-step protocol for the synthesis of benzylic sulfonamides was developed to access MK-8033 and analogues. Importantly, MK-8033 provides full inhibition of tumor growth in a c-Met amplified (GTL-16) subcutaneous tumor xenograft model and may have an advantage over inactive form kinase inhibitors due to equal potency against a panel of oncogenic activating mutations of c-Met in contrast to c-Met inhibitors without preferential binding to the active kinase conformation. References: J Med Chem. 2013 Mar 28; 56(6):2294-310; J Thorac Oncol. 2012 Aug; 7(8):1211-7. Related CAS#:1283000-43-0 (HCl salt)
	Name: MK-8033 CAS#: 1001917-37-8 (free base); Chemical Formula: C25H21N5O3S Exact Mass: 471.13651 Molecular Weight: 471.53094 Elemental Analysis: C, 63.68; H, 4.49; N, 14.85; O, 10.18; S, 6.80
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: MK-8033; MK8033; MK 8033. IUPAC/Chemical Name: 1-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4, 5]cyclohepta[1, 2-b]pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide InChi Key: VMJFTOSOFDEKTM-UHFFFAOYSA-N InChi Code: InChI=1S/C25H21N5O3S/c1-30-15-20(13-28-30)19-11-23-24(27-12-19)8-7-18-6-5-17(10-22(18)25(23)31)16-34(32, 33)29-14-21-4-2-3-9-26-21/h2-13, 15, 29H, 14, 16H2, 1H3 SMILES Code: O=S(CC1=CC=C2C(C(C3=CC(C4=CN(C)N=C4)=CN=C3C=C2)=O)=C1)(NCC5=NC=CC=C5)=O

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Amount: 5mg

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Delivery expected until 9/6/2024