mk0812

Item no.	V4298-10mg
Manufacturer	InvivoChem LLC
CASRN	624733-88-6
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4298CAS #:624733-88-6 Purity >=98% Description: MK-0812 is a novel, potent and selective small molecule CCR2 antagonist. MK0812 selectively reduced the peripheral blood monocyte frequency, and caused an elevation in the CCR2 ligand CCL2. The much greater impact of CXCR2/CXCR1 antagonism relative to CCR2 antagonism in this model of arthritis highlights the therapeutic potential for targeting CXCR2/CXCR1 in human arthritides. Neutrophils and monocytes are abundantly represented in the synovial fluid and tissue in rheumatoid arthritis patients. The effects of small molecule chemokine receptor antagonists such as MK-0812 to block migration of these cells in anti-collagen antibody-induced arthritis were explored. Description: References: J Immunol Methods. 2010 Jan 31; 352(1-2):101-10.; Biochem Biophys Res Commun. 2010 Jan 1; 391(1):1080-6. References: Related CAS#:851916-42-2 (succinate)
	Name: MK-0812 CAS#: 624733-88-6 (free base); Chemical Formula: C24H34F3N3O3 Exact Mass: 469.2552 Molecular Weight: 469.5492 Elemental Analysis: C, 61.39; H, 7.30; F, 12.14; N, 8.95; O, 10.22
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: MK-0812; MK 0812; MK0812. IUPAC/Chemical Name: ((1S, 3R)-1-isopropyl-3-(((3S, 4S)-3-methoxytetrahydro-2H-pyran-4-yl)amino)cyclopentyl)(3-(trifluoromethyl)-7, 8-dihydro-1, 6-naphthyridin-6(5H)-yl)methanone InChi Key: MTMDXAIUENDNDL-RJSMDTJLSA-N InChi Code: InChI=1S/C24H34F3N3O3/c1-15(2)23(7-4-18(11-23)29-20-6-9-33-14-21(20)32-3)22(31)30-8-5-19-16(13-30)10-17(12-28-19)24(25, 26)27/h10, 12, 15, 18, 20-21, 29H, 4-9, 11, 13-14H2, 1-3H3/t18-, 20+, 21-, 23+/m1/s1 SMILES Code: CC(C)[C]1(CC[CH](C1)N[CH]2CCOC[CH]2OC)C(=O)N3CCC4=NC=C(C=C4C3)C(F)(F)F

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