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at-9283-l-lactate

at-9283-l-lactate

Item no.	V4262-5mg
Manufacturer	InvivoChem LLC
CASRN	896466-76-5
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	896466-76-5
Available
Description	InvivoChem Cat #:V4262CAS #:896466-76-5Purity >=98% Description: AT-9283 L-lactate is a novel, potent multikinase inhibitor with potential antineoplastic activity and has the potential for the treatment of multiple myeloma. It inhibits JAK2/3 with IC50 of 1.2 nM/1.1 nM in cell-free assays. AT9283 binds to and inhibits Aurora kinases A and B, JAK2 and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Description: References: J Med Chem. 2009 Jan 22; 52(2):379-88. References: Related CAS#:896466-61-8 (HCl); 896466-04-9 (free base)
Molecular Weight (MW)	471.52
Formula	C22H29N7O5
CAS No.	896466-76-5 (lactate)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 50 mg/mL
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	2% DMSO+30% PEG 300+ddH2O: 5 mg/mL
Synonyms	AT9283; AT 9283; AT-9283 lactate

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5mg

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