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at-9283-hcl

at-9283-hcl

Manufacturer	InvivoChem LLC
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
Amount	100mg
Item no.	V4261-100mg
CASRN	896466-61-8
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V4261CAS #:896466-61-8 Purity >=98% Description: AT9283 is a novel, potent multikinase inhibitor with potential antineoplastic activity and has the potential for the treatment of multiple myeloma. It inhibits JAK2/3 with IC50 of 1.2 nM/1.1 nM in cell-free assays. AT9283 binds to and inhibits Aurora kinases A and B, JAK2 and the kinase BCR-ABL, which may result in the inhibition of cellular division and proliferation and the induction of apoptosis in tumor cells that overexpress these kinases. Description: References: J Med Chem. 2009 Jan 22; 52(2):379-88. References: Related CAS#: 896466-04-9 (free base); 896466-76-5 (lactate)
Molecular Weight (MW)	417.89
Formula	C19H24ClN7O2
CAS No.	896466-61-8 (HCl);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 50 mg/mL
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	2% DMSO+30% PEG 300+ddH2O: 5 mg/mL
Synonyms	AT9283; AT 9283; AT-9283 HCl

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100mg

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