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bay-1251152-1610358-53-6

bay-1251152-1610358-53-6

Item no.	V4202-100mg
Manufacturer	InvivoChem LLC
CASRN	1610358-53-6
Amount	100mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V4202CAS #:1610358-53-6 Purity >=98% Description: (+/-)-BAY-1251152 is a racemic mixture of BAY-1251152 which is a novel, potent and highly selective PTEF/CDK9 inhibitor. BAY-1251152 shows significantly increased biochemical (IC50 CDK9 = 3 nM) and cellular potency (IC50 MOLM13 = 29 nM), increased selectivity against CDK2 as well as high permeability and no efflux. The significantly reduced therapeutic dose and high solubility of BAY 1251152 enable the desired i.v. application. BAY 1251152 demonstrated excellent efficacy upon i.v. treatment in xenograft models (e.g. MOLM13) in mice and rats. BAY 1251152 is currently being evaluated in Phase I studies (NCT02635672; NCT02745743) to determine the safety, tolerability, pharmacokinetics and initial pharmacodynamic biomarker response in patients with advanced cancer. PTEFb/CDK9 mediated transcription of short-lived anti-apoptotic survival proteins like Mcl-1 and Myc plays a critical role in cancer cell growth and survival in various tumor entities including AML. In addition, these survival proteins play important roles in the development of resistance to chemotherapy. Description: References: AACR; Cancer Res 2017; 77(13 Suppl):Abstract nr 984. doi:10.1158/1538-7445.AM2017-984 References: Related CAS#:1610358-56-9 (+)-BAY-1251152; 1610358-59-2 (-)-BAY-1251152
	Name: (+/-)-BAY-1251152 CAS#: 1610358-53-6 [(+/-)-BAY-1251152]; Chemical Formula: C??H??F?N?O?S Exact Mass: 404.1119 Molecular Weight: 404.4358 Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight:Elemental Analysis: C, 56.43; H, 4.49; F, 9.40; N, 13.85; O, 7.91; S, 7.93
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: (+/-)-BAY-1251152; (+/-)-BAY 1251152; (+/-)-BAY1251152; (-)-BAY-1251152; BAY-1251152; BAY 1251152; BAY1251152; (+)-BAY-1251152. IUPAC/Chemical Name: (+/-)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine InChi Key: YZCUMZWULWOUMD-UHFFFAOYSA-N InChi Code: InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2, 22)26/h3-10, 22H, 11H2, 1-2H3, (H, 23, 24, 25) SMILES Code: N=S(CC1=CC(NC2=NC=C(F)C(C3=CC=C(F)C=C3OC)=C2)=NC=C1)(C)=O

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Amount: 100mg

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